E155 and E215 at 6.03 Å - exactly the nucleophile/acid-base separation expected for a GH5 retaining endoglucanase. This step matters. If I had accepted the literature numbering without checking, I would have fixed the wrong residues and the constra...

Antimicrobial resistance is projected to kill 10 million people annually by 2050 - more than cancer. Antimicrobial peptides AMPs are one of the most promising therapeutic classes to fight it. They're cationic, membrane-disrupting, and bacteria strugg...

A step-by-step walkthrough of my multi-sample single-cell RNA sequencing project - written for anyone curious about how computational biology actually works Before we start - what is this article actually about? Imagine being able to take a tiny s...

One of the most frustrating puzzles in cancer biology: some lung cancer patients respond brilliantly to immunotherapy. Others don't respond at all. The tumour microenvironment TME, the ecosystem of immune, stromal, and cancer cells that surrounds a t...

Alzheimer's disease affects over 55 million people worldwide, yet the precise molecular changes happening inside individual brain cells remain poorly understood. I wanted to dig into that question - not at the tissue level, but at single-cell resolut...